The interior of a mammal's body is like a saltwater aquarium. Inside the skin cell tank the mammal cells, like the tiny rod-shaped unicellular Methanobrevibacter smithii, swim and float in a sodium solution. Enclosed in waxy membranes equipped with filtering devices, cells contain fluids of mostly potassium salts that ebb and flow within and without to maintain homeostasis and absorb and excrete substances.
Like an aquarium air pump, the heart and lungs pump oxygen throughout the body. Disposal systems, made up of the liver and bowel and other organs filter out waste. Body cells, bacteria, and yeasts [like odd sea creatures of the deep sea] coexist in this briny aqueous solution—not always harmoniously. Just as in the closed system of the saltwater aquarium problems arise when the temperature fluctuates widely, the pH is altered significantly, there is invasion of pathogens, or if physical damage impacts fluid flows, equipment, or systems. Then, conditions become favored for select organisms and imbalances create disease.
The cellular fluids and material components have a mathematic formula comprised of amino acids, sugars, fatty acids, enzymes, coenzymes (vitamins), inorganic elements (minerals), hormones, salts, lipids, phytonutrients, waste products and parasites, and less measurable properties. Foods also have a mathematical formula made up of amino acids, sugars, fatty acids, enzymes, coenzymes, inorganic elements, hormones, salts, lipids, phytonutrients, waste products and parasites, and less measurable properties.
The art of health, much like the art of maintaining a salt water aquarium, is the art of identifying specific imbalances and coordinating intakes of balancing substances such as fresh clean water, wholesome foods, and vitamin and mineral supplementation. Tailored to the individual environmental conditions, the appropriate intakes will correct imbalances and maintain homeostasis among these competing and complimentary interests.
Contributor: Laney Poiré
The TP53 gene provides instructions for making a protein called tumor protein p53. This protein, located inside the nucleus of cells in the body, regulates cell division and binds to DNA. When the DNA in a cell becomes damaged by toxic chemicals this protein is important in a determination of whether the DNA will be repaired, or the damaged cell will self-destruct.
If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, the p53 protein prevents the cell from dividing and signals it to self-destruct and helps to prevent the development of tumors.
It is now widely acknowledged that p53 mutations are the most common genetic event in human cancer. Yet, after three decades of intensive TP53 research, the function of p53 protein in cells is still not completely understood. It has been observed that inactivation of the p53 tumor suppressor gives rise to tumor formation.
Research supports a hypothesis that p53 mutations at early stages of tumor development endow cells with growth and survival advantages and contribute to uncontrolled cell proliferation, a feature of both benign and malignant tumors. Then, mutations at later stages synergize with additional oncogenic events to drive invasion and metastasis. These p53 mutations are present in greater than 50% of all human tumors, benign or malignant.
Wild-type p53 can be activated by a number of cellular stressors including DNA damage, oxygen deficiency, and tumor development activation. Following activation, wild-type p53 functions as a transcription factor to inhibit cell cycle progression, promote loss of a cell's power of division and growth, or induce cell death.
Importantly, not only has wild-type p53 been demonstrated to be inactivated in most tumors, but several in vivo studies have demonstrated that reactivation of wild-type p53 is sufficient to lead to tumor regression. This observation has paved the way for multiple approaches to activate wild-type p53 in tumor cells.
A strong association has been demonstrated between benzo(a)pyrene exposure found in cigarette smoke and p53 mutations.
The influence of psychosocial stressors on the development and progression of cancer has been a longstanding hypothesis since ancient times. Clinical studies over the past 30 years have provided strong evidence for links between chronic stress and many diseases, including cancers.
The mutation of p53 has a strong association with exposure to Aflatoxin B1 a carcinogenic agent present in a fungal species, Aspergillus flavus, and a common contaminant of food supplies. Aflatoxins are detected in milk, cheese, corn, figs, spices, red wines, peanuts and other groundnuts, tree nuts, maize, rice, figs and other dried foods, spices and crude vegetable oils, and cocoa beans. Milk, eggs, and meat products are sometimes contaminated because of the animal's consumption of aflatoxin-contaminated feed.
Mitigation of Negative Effects
It may well be that both psychological stress and environmental pollutants are at the root cause of tumors and cancers, and Aflatoxin B1 has been shown to be a highly prevalent carcinogen.
Stress management can be had through movement classes such as yoga, tai chi, qi gong. Physical exercise is a stress relieving activity. Prayer and meditation are excellent tools, and classes that teach coping skills can also be helpful. Acupuncture is also a good stress management tool.
Vitamin C is an important antioxidant that has been shown to be very effective at diminishing the effects of Aflatoxin B1. Vitamin C therapy has shown great promise in reduction of tumor growth and cancers.
The combination of stress reduction and Vitamin C therapies could go a long way toward preventing, mitigating, and potentially reversing the damaging effects to cells that leads to tumor growth and cancer.
Contributor: Laney Poiré
We need to take a bigger interest in our food chain. Seriously.
Taking an avid interest in where our food is sourced and how it is produced is beneficial for our health and the health of our planet. Our food chain has some serious problems. Our rampant chronic diseases, shared by our companion animals, are in part evidence of this problem.
We, and our companion animals, are suffering epidemics of degenerative diseases. We have super bugs that our antibiotics cannot kill as bacteria are becoming immune to pharmaceuticals. Healthy women are experiencing normal births and coming out of hospitals with flesh-eating disease. Our children have gout, obesity, and cancer. In the early 1960's the incidence of cancer in dogs was so rare finding a dog with cancer would warrant a journal article. Now, cancer is the leading cause of death in dogs.
Cancer is linked to toxins in our environment, our environment includes our diet. Our food is over-processed and full of chemicals, synthetic and artificial ingredients, molds, and bacteria.
Aflatoxin B1 bacteria is linked to many degenerative diseases and is found in nearly all food in the food chain. Our feed animals are kept in stressful, filthy conditions and fed toxin-filled nutrient deficient refuse from our food chain. Also, 90% of feed animal food is genetically modified (GMOs). GMO crops are classified with the USDA as pesticides, not food stuffs.
Avian Micobacterium Subspecies Paratuberculosis, MAP, known as "Johnes disease" in cattle and "wasting disease" in deer, along with the usual suspects such as salmonella, e.coli, and listeria, are so prevalent in our food chain that we irradiate and pasteurize our food as a matter of course.
Our soils are depleted of trace minerals and devoid of beneficial soil organisms. Our inner soils inside our mucous membrane reflect the insufficiency of the outer soil in their lack of healthy populations of beneficial organisms. Without these protective organisms we cannot fully receive the benefits of our food and our immune system is inadequate to protect us from the chemicals and toxins in our environment.
But what can I do?
As far as the food you consume, there are now available nearly everywhere in America farmers who are keenly aware of the serious problems in our food chain and the public health risks of them. These conscientious growers are offering clean, chemical-free local solutions. It is as simple as reaching out to them. Also, paying a bit more for clean organic foods available in supermarkets supports our smaller, healthier farms. Buying local from organic soil-based farms reduces the chance of negative health effects of toxins in the food chain and in the environment.
Try the following websites for more information:
Contributor: Laney Poiré
Within this blog you will find commentary on psychological and physiological stressors and therapeutic methods for remediation of dis-ease.